https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51575 Wed 29 May 2024 15:12:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51317  2) and hemorrhagic stroke. With four arms per stratum (reference arm retained throughout), only the single treatment arm demonstrating the highest proportion of favorable outcomes at the first stage will proceed to the second stage in each stratum, resulting in a final comparison with the reference arm. Three prognostic covariates of age, geographic region and reperfusion interventions, as well as previously observed mRS 0-2 responses inform the adaptive randomization procedure. Participants randomized receive prespecified mobility training regimens (functional task-specific), provided by physiotherapists/nurses until discharge or 14 days. Interventions replace usual mobility training. Fifty hospitals in seven countries (Australia, Malaysia, United Kingdom, Ireland, India, Brazil, Singapore) are expected to participate. Summary: Our novel adaptive trial design will evaluate a wider variety of mobility regimes than a traditional two-arm design. The data-driven adaptions during the trial will enable a more efficient evaluation to determine the optimal early mobility intervention for patients with mild and moderate ischemic stroke.]]> Wed 28 Feb 2024 15:05:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54154 Wed 28 Feb 2024 15:02:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23855 Wed 28 Feb 2024 14:37:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34551 Wed 27 Mar 2019 10:19:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45195 Wed 26 Oct 2022 14:33:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45004 P < .001). Most of this increase has come from procedures in New South Wales (441% increase). Australian PCI rate increased from 22 301 to 30 480. Rate of CABG decreased from 5418 to 5206. Conclusions: From 2007 to 2017, rates of RA trebled in Australia. This is despite stable rates of PCI and a fall in rates of CABG. There are several clinical explanations for this trend.]]> Wed 26 Oct 2022 09:49:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16435 Wed 24 Mar 2021 11:01:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46248 Wed 22 Mar 2023 18:23:00 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49447 Wed 17 May 2023 12:17:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36730 Wed 13 Mar 2024 19:12:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37901 Wed 13 Mar 2024 19:07:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41724 Wed 13 Mar 2024 11:19:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26131 Wed 11 Apr 2018 14:53:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23184 Wed 11 Apr 2018 14:48:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18031 Wed 11 Apr 2018 14:07:15 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30546 Wed 11 Apr 2018 12:58:57 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15292 Wed 11 Apr 2018 12:52:21 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9266 Wed 11 Apr 2018 10:08:53 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23231 Wed 11 Apr 2018 09:41:44 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36092 Chlamydophila pneumoniae (Cpn). The objective of the current study is to determine the effect of a combined antibiotic protocol (CAP) on the venous flow in MS patients as measured by a quantitative duplex ultrasound examination (QDUS). Method: A non-randomised before-after cohort study was conducted to investigate differences in blood flow volumes pre and 6-months post antibiotic treatment for Cpn infection. Flow volume data were measured by QDUS across affected and unaffected sides from multiple veins segments, including internal jugular vein (IJV) segments J2 and J3, and vertebral vein (VV), as well as global arterial blood flow (GABF). Results: 91 patients were included in the study. 64 (70%) were found to have positive Cpn serology. There was a statistically significant post-treatment difference seen for the affected side of Cpn infected patients (mean difference = 56 mL/min, p = 0.02). There was a non-significant increase seen for the affected side of uninfected patients (mean difference = 23 mL/min, p = 0.2). The difference in these effects (34 mL/min) was not statistically significant (p = 0.3). The mean flow rate decreased in the unaffected side for both infected (-27 mL/min, p = 0.5) and uninfected patients (-69 mL/min, p = 0.01). There was a statistically significant post-treatment increase in GABF for the infected patients (mean difference = 90 mL/min, p = 0.02) and a difference of 76 mL/min for non-infected patients (p = 0.01). Conclusion: A CAP appears to improve the extra-cranial circulation in patients diagnosed with MS. This effect is statistically significant in patients with positive Cpn serology, although patients with negative Cpn serology also show some benefit, betraying a lack of specificity of this effect.]]> Wed 05 Feb 2020 14:51:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38142 Wed 04 Aug 2021 16:03:42 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38118 Wed 04 Aug 2021 14:18:40 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45661 Wed 02 Nov 2022 15:52:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36523 Tue 26 May 2020 11:42:47 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50440 Tue 25 Jul 2023 19:14:12 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36181 in silico and in vitro studies have identified factor Xa as an appropriate activating agent, and the phospholipid Actin FS as a cofactor for a Xa clotting time (TenaCT) test. A proof-of-concept study was designed to (1) explore the reproducibility of the TenaCT test and (2) explore factors that could affect the performance of the test. In vitro clotting time tests were carried out using plasma from 20 healthy volunteers. The effect of enoxaparin was determined at concentrations of 0.25, 0.50, and 1.0 IU/mL. Clotting times for the volunteers were significantly prolonged with increasing enoxaparin concentrations. Clotting times were significantly shortened for frozen plasma samples. No significant differences in prolongation of clotting times were observed between male and female volunteers or between the 2 evaluated age groups. The clotting times were consistent between 2 separate occasions. The TenaCT test was able to distinguish between the subtherapeutic and therapeutic concentrations of enoxaparin. Plasma should not be frozen prior to performing the test, without defining a frozen plasma reference range. This stu dy provided proof-of-concept for a Xa-based test that can detect enoxaparin dose effects, but additional studies are needed to further develop the test.]]> Tue 25 Feb 2020 10:13:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31136 Tue 24 Mar 2020 13:00:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38172 Tue 23 May 2023 11:49:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43451 Tue 20 Sep 2022 08:34:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34202 A Primer on Partial Least Squares Structural Equation Modeling (PLS-SEM) Second Edition, this easy-to-understand, practical guide covers advanced content on PLS-SEM to help students and researchers apply techniques to research problems and accurately interpret results. The book provides a brief overview of basic concepts before moving to the more advanced material. Offering extensive examples on SmartPLS 3 software (www.smartpls.com) and accompanied by free downloadable data sets, the book emphasizes that any advanced PLS-SEM approach should be carefully applied to ensure that it fits the appropriate research context and the data characteristics that underpin the research.]]> Tue 19 Feb 2019 14:22:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44627 Tue 18 Oct 2022 11:22:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33329 Tue 16 Oct 2018 11:47:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43164 Tue 13 Sep 2022 15:49:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36572 Tue 09 Jun 2020 11:40:47 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45999 Tue 08 Nov 2022 16:18:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34034 Tue 03 Sep 2019 18:26:11 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34506 Tue 03 Sep 2019 18:01:42 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24870 Thu 28 Oct 2021 13:05:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24301 Thu 28 Oct 2021 12:36:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36272 Thu 28 Oct 2021 12:36:00 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50498 Thu 27 Jul 2023 10:57:53 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45682 Thu 25 Jan 2024 14:40:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54909 Thu 21 Mar 2024 11:56:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54905 Thu 21 Mar 2024 11:56:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36283 Thu 19 Mar 2020 17:51:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44414 Thu 13 Oct 2022 08:55:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38357 Thu 09 Sep 2021 12:21:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31303 Sat 24 Mar 2018 08:44:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31737 Sat 24 Mar 2018 08:43:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7407 Sat 24 Mar 2018 08:42:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10020 Sat 24 Mar 2018 08:12:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21404 n=3467, mean age 74 years [standard deviation 13], 50% female; intracerebral haemorrhage n=275, mean age 74 years [standard deviation 13], 48% female). Following multivariable analyses patients with intracerebral haemorrhage were less likely to be admitted to a stroke unit (adjusted odds ratio 0·65; 95% confidence interval 0·45-0·94) or receive an assessment from allied health (adjusted odds ratio 0·54; 95% confidence interval 0·33-0·89) than patients with ischemic stroke. Patients with intracerebral haemorrhage are also less likely to be independent (adjusted odds ratio 0·36; 95% confidence interval 0·3-0·5) at time of hospital discharge and had a greater odds of dying in hospital (adjusted odds ratio 2·1; 95% confidence interval 1·3-3·5). Patients that were admitted to a stroke unit had a greater odds of being independent (modified Rankin Score 0-2) at day 7-10 irrespective of stroke type or severity on admission (adjusted odds ratio 1·3; 95% confidence interval 1·01-1·66). Conclusions: Following intracerebral haemorrhage, patients were less likely to be admitted to an acute stroke unit and receive allied health interventions. Admission to stroke units improved the likelihood of being independent at days 7-10 and, therefore, more should be done to encourage evidence-based care for intracerebral haemorrhage.]]> Sat 24 Mar 2018 08:04:59 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20376 Sat 24 Mar 2018 07:58:11 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21868 Sat 24 Mar 2018 07:52:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21719 Sat 24 Mar 2018 07:52:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21189 Sat 24 Mar 2018 07:52:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18500 Sat 24 Mar 2018 07:51:22 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16433 Sat 24 Mar 2018 07:51:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16432 Sat 24 Mar 2018 07:51:16 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19980 Sat 24 Mar 2018 07:50:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6414 Sat 24 Mar 2018 07:45:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30631 Sat 24 Mar 2018 07:39:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31110 Sat 24 Mar 2018 07:35:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27009 Sat 24 Mar 2018 07:34:47 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25725 Sat 24 Mar 2018 07:33:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29500 Sat 24 Mar 2018 07:29:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27241 Sat 24 Mar 2018 07:29:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24276 Sat 24 Mar 2018 07:14:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23607 Sat 24 Mar 2018 07:13:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23097 Sat 24 Mar 2018 07:12:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24729 Sat 24 Mar 2018 07:10:57 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24697 F0 = 0.017) and 3 months (Pr>F = 0.006), indicating more consistent and predictable improvement in motor outcomes. Conclusion: Early, more-intensive, UL training was associated with greater changes in activation in putative motor (supplementary motor area and cerebellum) and attention (anterior cingulate) regions, providing support for the role of these regions and functions in early recovery poststroke.]]> Sat 24 Mar 2018 07:10:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23175 Sat 24 Mar 2018 07:10:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49523 Sat 20 May 2023 12:39:02 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45782 Sat 05 Nov 2022 12:35:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38356 Mon 30 Aug 2021 16:11:44 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38338 -4, hazard ratio = 1.41). Moreover, rs7298096AA is associated with a higher NINJ2 expression in blood (p = 7.0 x 10^-6), which was confirmed in vitro (p = 0.009). Finally, NINJ2 expression is downregulated by IFNβ treatment and related to TTFR. Conclusions: Rs7298096 could influence MS disease activity during IFNβ treatment by modulating NINJ2 expression in blood. The gene encodes for an adhesion molecule involved in inflammation and endothelial cells activation, supporting its role in MS.]]> Mon 30 Aug 2021 13:46:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37911 Mon 29 Jan 2024 18:04:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36512 Mon 25 May 2020 13:11:48 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32606 Mon 25 Jun 2018 12:15:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25456 Mon 23 Sep 2019 12:57:08 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47482 Mon 23 Jan 2023 11:47:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49585 Mon 22 May 2023 12:22:22 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42307 Mon 22 Aug 2022 09:28:12 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53763 Mon 15 Jan 2024 09:56:01 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46290 Mon 14 Nov 2022 16:30:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40225 Mon 11 Jul 2022 12:37:44 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52276 Mon 09 Oct 2023 10:02:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40707 Mon 08 Aug 2022 10:22:42 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36790 Mon 06 Jul 2020 11:10:41 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53530 Mon 04 Dec 2023 15:38:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35000 Fri 31 May 2019 09:33:04 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36538 Fri 29 May 2020 17:22:29 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45496 Fri 28 Oct 2022 15:53:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45441 Fri 28 Oct 2022 13:54:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41076 Fri 22 Jul 2022 17:04:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44525 Fri 14 Oct 2022 13:58:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45742 Fri 04 Nov 2022 10:12:57 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36373 Fri 03 Apr 2020 13:50:40 AEDT ]]>